Mesopotamia was located in southwest Asia. The two main rivers I Mesopotamia are the Tigris and the Euphrates rivers. Mesopotamia means "between rivers" in Greek. The climate was cool and warm depending on the season,they also had moderate rainfall. If you look on a map today, you will see that Iraq is located where Mesopotamia used to be. The distance between Elm City,NC and Iraq is approximately 6,400 miles.