The original was an extract of willow bark. This was used in ancient times and became more popular over centuries Modern aspirin was first prepared in 1853 by a French Chemist, Charles, Gerhardt. The things required for a civilization are cities, writing, religion, a political structure, a materialist value, an economy, and art. It was the first time that a states laws were set down in writing it also was because it brought justice and fairness to them.
This a timeline chart that showes time of at least four civlization
Civilization of Mesopotamia
Gilgamesh was the fifth king of Uruk, modern day Iraq.