Sickle-cell disease

By Trinity and Victoria

The symptoms of Sickle-cell disease

The most common symptom of anemia is fatigue. Others are Shortness of breath, Dizziness, Headaches, Coldness in the hands and feet,Paler than normal skin or mucous membranes (the tissue that lines your nose, mouth, and other organs and body cavities), and Jaundice (a yellowish color of the skin or whites of the eyes). Sickle cell anemia is present at birth, but many infants don't show any signs until after 4 months of age.

The Life Expectancy of Sickle-Cell Disease

The median age at death was 42 years for males and 48 years for females. Among those with sickle cell-hemoglobin C disease, the median age at death was 60 years for males and 68 years for females.

Images of Sickle-cell disease

How common is Sickle-cell disease?

It is most common among people whose ancestors come from Africa; Mediterranean countries such as Greece, Turkey, and Italy; the Arabian Peninsula; India; and Spanish-speaking regions in South America, Central America, and parts of the Caribbean.

More things about sickle-cell disease

  1. Which chromosome(s) is this disorder on? How is it inherited? Is it a single gene or multiple genes? Is it recessive or dominant? Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11. Hemoglobin transports oxygen from the lungs to other parts of the body. Red blood cells with normal hemoglobin are smooth and round and glide through blood vessels.
Sickle Cell Disease

Is there a cure?

This treatment may even offer a cure for a small number of people. The stem cells used for a transplant must come from a closely matched donor.