Garcinia Cambogia Extract

Weight Loss Review

The History Of Garcinia Cambogia weight loss

In Ayurveda, it is said that the sour flavors, such as those from Garcinia, activate digestion. Garcinia has also been considered to make foods more filling and satisfying, and has been used routinely for many centuries with no known toxicity. This herb has been used historically in India to support the treatment of various health conditions. This substance inhibits the activity of cytrate–liase, one of the key enzymes of the cytrate transport mechanism. The biologic role of the cytrate transport system is to supply acetyl–CoA to the synthesis systems of cytoplasm, which is the most important source of carbon atoms in the lipids molecules and the unique source of carbon in the cholesterol molecules. Additionally, the cytrate transport mechanism produces approximately half of NADPH in the cells. NADPH is cofactor of the reductases of the fatty acids biosynthesis way and cofactor of 3 –methyl – 3- glutaryl coenzyme A reductase, which is the regulatory enzyme of cholesterol biosynthesis and the well–known target of the hypocholesterolemic drugs.

The low concentration of NADPH may also bring about the restriction of the lipids biosynthesis. In conclusion, since hydroxycitric acids reduce the activity of the cytrate-liase cycle, the concentration of Acetil-CoA in the cytosol of the cells also becomes lower, and all this also causes the reduction of the substratum’s availability to work for the mechanisms of the lipidic synthesis. Therefore, the synthesis of triglycerides and cholesterol is finally reduced. Garcinia Cambogia weight loss reduces appetite, even though its mechanism of action has not been totally defined. It probably intervenes in the serotoninergic transmission in the structures of the brain.Products from Garcinia cambogia are well tolerated; however, since the extract can increase the arterial pressure, it is recommended to use them with caution and to consult a physician in cases of arterial hypertension or arterial ischemia.




Garcinia Cambogia Extract Review: Weight Loss vs Health Optimization Rant