Come to Party with Herpesviridae
Hang out with the large family of DNA viruses!
Here's What Goes on at the Party!
The viruses in the Herpesviridae family are all large viruses with a linear double-stranded DNA genome. They are enveloped viruses that can exhibit pleomorphism - shape and size may alter with every passing generation. One key trait of the family is the ability to infect the host with a latent infection and remain in host cells for the life of the host.
Event Information
Herpesviridae Party in Human 300940
You can get here by being spread by direct contact or through bodily fluids, namely saliva.
When?
Friday, Dec 11, 2015, 09:00 PM
Where?
South Hunterdon Regional High School, Mount Airy-Harbourton Road, Lambertville, NJ, United States
HSV-1 & HSV-2
One species of the Herpesviridae family is the herpes simplex virus. Oral herpes involves the face and mouth and may result in small blisters in groups called cold sores or fever blisters. HSV-1 is one type of the herpes simplex virus that more commonly causes oral infections. HSV-2 type tends to cause genital infections. Worldwide rates of either type are between 65% and 90% in adults.
Varicella-Zoster virus
Varicella-zoster virus is another member of the family. VZV only affects humans and commonly causes chicken pox in children, teens, and young adults and herpes zoster (shingles) in adults - rarely in children. VZV multiples in the lungs and causes a wide variety of symptoms. After the primary infection in childhood (chicken pox), the virus goes dormant in the nerves. Many years later, it can reactivate to cause shingles or other neurological conditions.
Epstein-Barr virus
This virus is best known as the cause of infectious mononucleosis - or "mono," the kissing disease. Most people become infected by EBV and gain adaptive immunity. 90% of adults have evidence of previous infection. EBV effects B Cells of the immune system and epithetical cells. Once the initial lytic infection is brought under control, the virus persists latently in the individual's B cells for the rest of their life. EPV has also been linked to multiple types of cancer.
Virus Life Cycle - The Party Never Ends!
Here's how it goes...
- The virus invades the cell by fusing its envelope with the cellular envelope.
- Once envelope fusion is completed, the viral tegument and capsid are transported to the nucleus of the infected cell using cytoskeletal proteins.
- The capsid injects the linear viral DNA into the nucleus.
- A product protein of the UL41 viral gene affects multiple cellular functions, including shutoff of host protein synthesis, degradation of host mRNA.
- Viral DNA is replicated and must be packaged into a new capsid.
- Once the capsid has left the nucleus, it must receive its tegument and secondary envelope.
- Virus begins the lytic cycle.
- Latency is achieved when the virus migrates in peripheral nuerons that innervate the epithelial cells where the infection is active.
- End of lytic cycle.
- Viral genes are deactivated during latency, to prevent the lytic cycle from activating in the neuron.
HEALTH MESSAGE DISCLAIMER
Once you come to the party, you never leave! We stay in this host until the day they die... unless they exchange body fluids with another host. In that case, some of us can explore a new body. Keep an eye out for any pesky drugs trying to ruin our fun.