Pancreatic Cancer

By lucas sanchez

Cause and Core Symptoms

Pancreatic cancer occurs when cells in your pancreas develop mutations in their DNA. These mutations cause cells to grow uncontrollably and to continue living after normal cells would die. These accumulating cells can form a tumor. Once you have pancreatic cancer some symptoms you may have could be...

  • Yellowing of your skin and the whites of your eyes (jaundice)

  • Loss of appetite

  • Weight loss

  • Depression

  • Blood clots

Cell Signaling Pathway Involved

Transforming growth factor beta(TGF-B).Alterations of the TGF-B and TGF-B receptors/Smad4 signal transduction pathway have been observed in pancreatic cancer.

Correct and Incorrect Mechanism

correct mechanism-TGF-B regulates cell growth and differentiation in healthy tissues


Incorrect mechanism-The mechanisms of pancreatic cancer progression remain unknown, but it is assumed that TGF-B fails to regulate cell growth in cells affected with the cancer. It impacts the epithelial cells comprising the tumor, and may affect the surrounding stromal cells.

current direction of research

Doctors are working to learn more about pancreatic cancer, ways to prevent it, how to best treat it, and how to provide the best care to people diagnosed with this disease.


  • Early detection
  • Genetic/molecular studies
  • Immunotherapy
  • Targeted therapy
  • Gene therapy
  • Chemotherapy
  • Cancer stem cells
  • Supportive care