Cri-Du-Chat Syndrome

By Noah Nelson, Alex Spurlock, and Marcus Morrow 3A

Ten Interesting Facts

  • In 80% of Cri Du Chat cases the chromosome carrying the deletion of the chromosome comes from the father's sperm rather than the mother's egg.

  • The disease becomes less noticeable as the baby gets older.

  • Cri-du-chat is French for the cry of the cat.

  • Geneticist Jerome Lejeune identified cri-du-chat (he also identified down syndrome)

  • 13% result from an error of chromosome 5 from the parent.

  • It is thought that girls receive this disease more than boys.

  • At present it is not possible to predict how severely affected the baby will be.

  • The main issues are located in band 5p 15.2.

  • Cri Du Chat is the most common syndrome cause by a chromosomal deletion.

  • It is possible to detect it with amniocentesis (chorionic villus sampling or CVS)

Life Expectancy and Treatments

A small amount of children are born with serious organ problems that are life threatening, but most individuals have a normal life expectancy.

Most fatal complications occur before their one years of age.

What are the treatments for Cri Du Chat?

The treatments (therapies) that these kids need, differ from each kid.

Some therapies they might have are-


occupational therapy

speech therapy






Cry of the cat syndrome is a disease that is passed down from the father's side that causes a brain setback and speaking issues along with a cry that sounds like a cat meowing. This disease only occurs 1/20,000-50,000 newborns. So it is not very common but is more common then other diseases.

Genetic Transmission

The gene that causes Cri-Du-Chat syndrome is passed down from the father's sperm and affects the 5th chromosome of the child

Written by Noah, Marcus, and Xander