The Rabies Virus

Symptoms

Symptoms

  1. Fever
  2. Headache
  3. Excess salivation
  4. Muscle spasms
  5. Paralysis
  6. Mental confusion.

Structure of the virus

The Rabie Virus is approximately 180 nm long and 75 nm wide. The rabies genome encodes five proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G) and polymerase (L). All rhabdoviruses have two major structural components: a helical ribonucleoprotein core (RNP) and a surrounding envelope. In the RNP, genomic RNA is tightly encased by the nucleoprotein. Two other viral proteins, the phospoprotein and the large protein (L-protein or polymerase) are associated with the RNP.

Host

The fusion of the rabies virus envelope to the host cell membrane (adsorption) initiates the infection process. The interaction of the G protein and specific cell surface receptors may be involved. After adsorption, the virus penetrates the host cell and enters the cytoplasm.

Replication

The fusion of the rabies virus envelope to the host cell membrane (adsorption) initiates the infection process. The interaction of the G protein and specific cell surface receptors may be involved. After adsorption, the virus penetrates the host cell and enters the cytoplasm by pinocytosis (via clathrin-coated pits).

Injury Claim

Pain areas: in the muscles

Whole body: dizziness, fatigue, fever, loss of appetite, or malaise

Psychological: delirium, fear, or hallucination

Gastrointestinal: nausea or vomiting

Muscular: muscle spasms or paralysis with weak muscles

Behavioral: aggression or irritability

The Rabies Virus

Treatment and Prevention

Prevention --- Depends on decreasing the disease in the animal kingdom. Avoid contact with wild animals and strays. Have your pets (including cats, dogs, and ferrets) vaccinated against rabies. Keep pets under control and away from wild animals and strays.


Treatment --- The most common treatment of rabies is with postexposure prophylaxis The first step in treating rabies and to reduce the likelihood of developing symptoms is to wash the wound with soap and water

Victims

is transmitted by domestic dog, where children between the age of 5–14 years are frequent.