Fibrodysplasia Ossificans Progressiva

What is it?

Fibrodysplasia Ossificans Progressiva (FOP) is a rare disease that turns your muscles, tendons, ligaments, and connecting tissues to bone.

What Systems does FOP affect?

The body system Fibrodysplasia Ossifican Proggresiva affects the muscular system. In an average person they have muscles that connect to tendons which connect to joints, and this allows the body to move. The muscles tendons and joints in a person with FOP don't work the same as normal people. Over time the muscles start to turn into bone. Eventually all of their muscles will turn to bone and this will kill them.

Target Population

FOP is a disease you are born with. Researchers are working to find out if this disease is genetic or if it just comes out of the blue.
FOP Facts & Insights: FOP Misdiagnosis: Issues and Consequences


The disease FOP is a very rare disease so it is commonly misdiagnosed. Once misdagnosed doctors send the patient with FOP to tumor specialists. The patient is then put through many examinations to see what's wrong with them. Once diagnosed with FOP the patient is heled with any exercise or physical movement.
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Right now FOP does not have a treatment or cure. Researchers have been working for 15 years trying to make a cure. People who have FOP most commonly live till mid 40's early 50's.

Signs and Symptoms

The first sign of FOP is crooked big toes. Then you will start to see unusual formation ofor bumps in a person's back, neck, and hips. By the age of ten you will start to see the "second skeleton" growing in.


This disease is a genetic disease that's present in infants. You start seeing this disease form at the age of ten and beginning of puberty.