Osteogenesis imperfecta

(Deformed Bones)

Description

Osteogenesis imperfecta is a genetic disorder that is characterized by bones that break easily, little to no apparent cause. It affects the body's ability to make strong bones.

Number of People affected in US

the number is unknown but the number is somewhere between 20,000 and 50,000.

Type I

Type I is the most common and is the mildest. Causes looses joints and muscle weakness.

Type II

Type II is the most severe form. Collagen is improperly formed.

Type III

Type III causes bones to fracture easily, spine curvature, and a triangular face. May also cause hearing loss

Type IV

Type IV is between I and III in severity. Also causes the bones to fracture easily. (Most occur before puberty) Causes mild to moderate bone deformity. Collagen is also improperly formed.

Type V

Type V is very similar to IV. Bones look mesh-like when viewed under a microscope. Dominant inheritance pattern.

Type VI

Type VI is also very similar to IV. Bones have a distinct fish-scale look. Whether it is recessive or dominant is still unknown.

Type VII

Type VII resembles IV. Short humerus and femurs. It is recessive inherited.

Type VIII

Type VIII resembles the lethal II and III. The Skeleton is under extreme mineralization.

Treatments

There is no cure for Osteogenesis imperfecta. Exercising as much as possible is encouraged. Also a healthy diet helps. Smoking, alcohol, caffeine consumption, and steroid medications cause bone depletion

Famous people with OI

Michael J. Anderson

Doug Herald

Nabil Shaban

Atticus Schaffer