This cartoon is from 2013. The quote at the bottom of the cartoon was said by Obama. He thinks that it's possible to find a compromise between the two parties (republican and democratic) but he's scared to take risks against the Republican Party. The Republicans are represented by an elephant who is bullying the small and skinny Obama.
The humor in this cartoon is the elephant (republicans) bullying Obama
In the cartoon they made the elephant big and strong looking and made Obama very skinny and helpless.
The artist reversed the roles of a person and an animal by making the animal beat the person up, not only a person but the president who usually has power and control.