Tiotropium Bromide

what is this drug?

Understanding Tiotropium Bromide

Trade Name: Spiriva

Generic Name: Tiotropium Bromide

Classification: Long Acting Muscarinic Antagonist


Uses: it is used as a bronchodilator therapy for maintenance treatment in COPD, chronic bronchitis and emphysema


Routes/Dosages: it is used as a dry powder inhaler, dosed at 18mcg/ inhalation and 1 inhalation daily (1 capsule)


Pharmakokinetics: once tiotropium bromide is inhaled, the drug will bind to (muscarinic) m1, m2 and m3 receptors in the airway, thus causing bronchodilation for up to 24 hours.

Onset- 30 minutes

Peak- 3 hours

Duration- 24 hours


Contraindications/Precautions:

Before administration of tiotropium bromide, tell your doctor if you are allergic to it, ipratropium; or to atropine or other belladonna-type drugs or if you have any other allergies. This drug may also contain inactive ingredients (milk proteins). They may cause allergic reactions. Talk to pharmacist for more details.


Before using this medication, tell your doctor or pharmacist your medical history, kidney diseases, personal or family history of glaucoma, or difficulty urinating

This drug may make you dizzy and may cause blurred vision. Do not operate or drive machinery that utilizes open alertness


Side effects include: dry mouth, pupillary dilation, lens paralysis, sore throat, hoarseness, increased intraocular pressure, increased heart rate, sinus infection, urinary retention, and altered mental status


Drug Interactions: Avoid w/ other anticholinergic-containing drugs; may lead to an increase in anticholinergic adverse effects. Can be used with sympathomimetics, methylxanthines, and steroids.


References: http://www.drugs.com/monograph/tiotropium-bromide.html

http://www.rxlist.com/spiriva-drug/medication-guide.htm

RSPT 2217 - drug flyer rubric.pdf

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