Hemophilia

Hemophilia

Hemophilia is a common inherited bleeding disorder.

Hemophilia

Hemophilia can result in Joint swelling that can lead to damage or swelling in the muscle,
bleeding in the head and sometimes in the brain leading to brain damage,
damage to other organs in the body, which cause pain, and death can occur if bleeding is not stopped.

Symptoms

Symptoms is pain, vomiting, changes in behavior, weakness, clumsiness, and seizures.

Signs of bleeding is if there is bleeding in the mouth, nosebleeds, heavy bleeding from a cut, in the urine, or large bruises.

The Cause

Hemophilia is caused by a problem in one of the genes which tells the body to make the clotting factor proteins needed to form one of the blood clot. Also its cause by a permanent gene changes or mutations.

Inheritance

Hemophilia is a sex linked disorder males of all races and ethnic groups. It is found on the X chromosomes. You inherit the mutated gene, the mother is the carrier of the hemophilia gene and can pass it to their children. Females rarely have hemophilia, the males usually have it. Females do not usually have hemophilia because it would have to have both the x chromosomes be affected and mutated. Hemophilia is inherited in a recessive pattern.

Diagnosis

For diagnosis you can do screening test and clotting factor tests. These tests show the type of hemophilia and how severe it is. Usually newborn babies are checked especially if they show any symptoms to hemophilia. If there is a history of bleeding disorders in your family then usually doctors will test for Hemophilia.

Treatment

Hemophilia can be treated by a replacement therapy. Concentrates of the clotting factor are slowly dripped or injected into a vein. The infusions help replace the clotting factor that is missing or are low. Antibodies can destroy the clotting factor before it even trys to work. Gene therapy has worked for the cure of hemophilia. Gene therapy is the most common cure for Hemophilia.

Demographics

Hemophilia occurs among 1 of every 5,000 male births. Today around 20,000 males in the United States have hemophilia. Hemophilia A is about four times as common as hemophilia B, and about half of the people are affected by the severe form. Hemophilia usually affects people from all racial and ethnic groups.