Hemophilia

The background information behind it

What is this disorder?

The genetic disorder hemophilia is a disorder in which the carrier of this disorder's blood can't clot properly, excessive bleeding (external and internal) occurs after any injury or damage. Can be inherited from either a female who has hemophilia or is a carrier and from a hemophiliac male.

History of Hemophilia

Although it was first noticed in 2nd century, it wasn't recognized until the 12th century by an Arab physician Albucasis as he wrote of a family who's father died after minor bleeding. Later in 1803, a Philadelphia physician named Dr. John Conrad Otto wrote an account of a hemorrhagic disposition existing in certain families. He discerned it was most relavent in men. He traced the disease back through three generations to a woman who had settled near Plymouth, New Hampshire, in 1720.

Chromosomes

Symptoms/Diagnosis

Symptoms include many large or deep bruises, joint pain and swelling, unexplained bleeding, and blood in urine or stool and must be diagnose medically. Hemophilia is diagnosed with blood tests to determine if clotting factors are missing or at low levels, and which ones are causing the problem.

Prognosis/Treatment

Although it cannot be eradicated from one's body, the individual can treat hemophilia by injections of a clotting factor or plasma called replacement therapy. Concentatres of clotting factor VIII (for hemophilia A) or clotting factor IX (for hemophilia B) are slowly dripped or injected into a vein. These infusions help replace the clotting factor that's missing or low.