Zika Virus

By: Maddie Flores

Classification of the Virus

Scientific Name: Zika virus

Family: Flaviviridae

Why Flaviviridae?

It is transmitted through arthropod vectors

Diseases Caused

Zika Fever and Guillain-Barre syndrome in adults and Microcephaly in pregnant women.


Fever, rash, joint pain, conjunctivitis (red eyes), muscle pain, or headache

Genetic Makeup of Zika

-E dimer

-M protein

-C protein

-Genomic RNA


Transient infection comes from monkeys, humans, and maybe rodents. Life-long infection comes from mosquitoes from the Aedes genus.

Infection directly affects keratinocytes and dendritic cells at the site of infection and then spreads to the lymph nodes and later, the bloodstream.

Mode of Infection

1. Attachment of the viral envelope to host receptors mediates internalization into the host cell by apoptotic mimicry

2. Fusion of the virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.

3. The ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins.

4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).

5. The dsRNA genome is replicated, providing viral mRNAs.

6. Virus assembly occurs at the endoplasmic reticulum and is transported to the Golgi apparatus.

7. The prM protein is cleaved in the Golgi, thereby maturing the virion which is fusion competent.

8. Release of new virions by exocytosis.

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Cure and Prevention

As of right now, there is no cure for Zika virus. Despite this factor, Zika is easily prevented by taking any actions to prevent mosquito bites.


"ViralZone: Zika Virus (strain Mr 766)." ViralZone: Zika Virus (strain Mr 766). ExPASy, 2016. Web. 21 Mar. 2016.

"Prevention." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 03 Mar. 2016. Web. 21 Mar. 2016.