Coeliac Disease

By Andrew Wagner

What is coeliac disease?

Coeliac disease is a common digestive condition where a person has an adverse reaction to gluten.

Coeliac disease mainly affects the small intestine( part of the gut )

What happens to the body?

Eating foods containing gluten can cause people with coeliac disease to have; diarrhea, bloating and the passing of wind , abdominal pain, weight loss, feeling tired all of the time.

What part of the body does it affect?

Coeliac disease mainly affects the small intestine (part of the gut).

All of the possibly effects on the body? What happens to the body in the body to cause it?

"The lining of the small intestine contains millions of tiny tube-shaped structures called villi." These help food and nutrients to be digested more effectively into the body. But, in people with coeliac disease, the villi become flattened as a result of the inflammation

Is it a mutation?

Research shows coeliac disease is strongly associated with a number of genetic mutations.

Is it located on a certain chromosome?

Yes,it is located on chromosome 6p21.

Is it a recessive or a dominate trait.

"Celiac disease is dependent on the inheritance of HLA-DQ proteins. Depending on the parental genotypes, the disorder based on HLA-DQ2 can be inherited in an autosomal-dominant or autosomal-recessive manner. HLA-DQ8 proteins, which also cause the disorder, are inherited on an autosomal-dominant basis."

Is it sex-linked?

"The fact that none of the known genes that link to it are on the X or Y chromosome mean that it's not sex linked in a genetic sense."

how is it treated?

"Since there is no cure for celiac disease, the goal of treatment is to reduce the symptoms. It may take up to 6 months or longer for your intestines to function better. You may need medicine such as steroids to suppress your immune system and decrease inflammation".

How common is it?

Coeliac disease affects about 1 in 100 people in the UK. It can be diagnosed in any age group but is more common in adults.More than 2 million people in the United States have the disease, or about 1 in 133 people.

How is it diagnosed?

If coeliac disease is suspected, a blood test to detect a certain antibody that occurs in coeliac disease may be advised by your doctor. It is important that you are eating a diet containing gluten for at least six weeks before the blood test is performed.