and its effects...

What is Dwarfism?

Dwarfism is a hereditary mutation that causes its victims to have a short stature. The average height of adults with Dwarfism is no taller than 4 feet and ten inches.

Symptoms of Dwarfism

  • A large head with a prominent forehead
  • A flattened bridge of the nose
  • Protruding jaw
  • Crowded and misaligned teeth
  • Forward curvature of the lower spine
  • Bowed legs
  • Flat, short, broad feet
  • "Double-jointedness"

Statistics On Dwarfism

Dwarfism is not a common disease, for there are only 200,000 cases of dwarfism per year in the United States alone. Only 40,000,000 people are estimated to have dwarfism in the world. As a matter of fact, only 1 per 40,000 births in the United States are cases of dwarfism.

Dwarfism and The Amish People

Dwarfism is most prevalent in the Amish people of Ohio and Canada, for it is estimated that 5 in 1000 (13%) Amish births are cases of Dwarfism.

Biology of Dwarfism

There are over 200 conditions that can cause dwarfism, and there are two main categories of Dwarfism. These categories include proportionate and disproportionate. Proportionate is when the whole body is short, and the limbs are proportionately short as well. Disproportionately dwarfism is when certain parts of the body are at certain heights and other parts of the body are disproportionately shorter than they should be. Achondroplasia is a single gene disorder caused by mutations in the FGFR3 gene. On chromosome.

Two different mutations in the FGFR3 gene cause more than 99 per cent of cases of achondroplasia.

It is a dominant genetic disease so only one copy of the FGFR3 gene needs to be mutated for symptoms to develop.

Achondroplasia can be inherited from a parent with the disease. However, most cases of achondroplasia are the result of a new mutation in the FGFR3 gene, over 80 per cent of people with achondroplasia have parents who are unaffected.

Type of Mutation

Most dwarfism-related conditions are genetic disorders, but the causes of some disorders are unknown. Most occurrences of dwarfism result from a random genetic mutation in either the father's sperm or the mother's egg rather than from either parent's complete genetic makeup. About 80 percent of people with achondroplasia are born to parents of average height. A person with achondroplasia and with two average-size parents received one mutated copy of the gene associated with the disorder and one normal copy of the gene. A person with the disorder may pass along either a mutated or normal copy to his or her own children.

Treatment Options For Dwarfism

There is no cure for dwarfism. However, growth hormones can help people with Dwarfism to achieve moderate growth in some children.Surgery is a treatment option in some cases to increase leg length by up to 30 cm, prevent spinal compression, or correct bowed legs. In some people with dwarfism, it may be necessary to drain fluid from the head to: relieve pressure on the brain, and you should make sure to frequently test for hydrocephalus- a condition where spinal fluid builds up inside the skull.


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