Werner's Syndrome

By: Ian Schroers period 1 Bio H.

Introduction to Werner's Syndome

Werner's Syndrome is a genetic disorder that causes premature aging and growth stunts. Usually occurring during or after puberty in people that have the disorder. Approximately 1 in 20,000 people in the U. S. has Werner's Syndrome.

Symptoms of Werner's Syndrome

Overall the symptoms relate to premature aging. This can include shortness, usually less 1.6 meters tall. Other symptoms can include thin skin, skull being malformed. Higher then normal pitch in voice, graying of hair, loss of hair, and winking of skin (premature aging in face). The syndrome onsets anywhere from in the mid teen age range to as old as 30.

Biology of Werner's Syndrome

The protein the condition affects is it makes a lack of the WRN protein. WRN is used for a variety of purposes such as DNA replication, transcription, recombination, and repair. Due to the lack of this protein the aging process is accelerated to a faster than normal speed.

Type of Inheritence of Werner's Syndrome

It is a autosome recessive disorder. This means that in order for a person to get Werner's Syndrome they have to have both recessive alleles for the trait. This is shown in the pedigree to the right.

Diagnosis and Treatment for Werner's Syndrome

It is diagnosed using a variety of methods such as physical characteristics, personal health history, and family history to see if it's a possibility, and laboratory tests such as DNA analysis. There is no specific cure or treatments for the disorder, however the symptoms of premature aging are minimalized by using medications. Some of the most common used are Thiazolidinedione, Rosiglitazone, Avandia, Pioglitazone, and Actor. There is few ethical implications of the treatments. There are some cases diagnoses could not be ethical is when physical characteristics are being used to diagnose. In that these observations may lead to a misdiagnosis when using physical characteristics only.

Bibliography (APA Format)

Janniger, C. K., Dr. (2015, October 22). Werner Syndrome Clinical Presentation. Retrieved March 20, 2016, from http://emedicine.medscape.com/article/1114125-clinical#b4

Luo, J. (2014, December 14). WRN protein and Werner Syndrome. Retrieved March 20, 2016, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237395/

Statistics about Werner Syndrome. (n.d.). Retrieved March 20, 2016, from http://www.rightdiagnosis.com/w/werner_syndrome/stats.htm

Werner Syndrome. (n.d.). Retrieved March 20, 2016, from http://wilsongen677s10.weebly.com/

(2016, March 14). Retrieved March 20, 2016, from https://ghr.nlm.nih.gov/handbook/consult/diagnosis