Hope for Overeaters?

Taylor Thompson

Article Summary

Enzymes and hormones may have a significant effect on over-eating. In this study, researchers found out that an enzyme plays an important role in how the brain responds to hormones. The hormone leptin has the function to send a signal to the brain to tell us that we’re full and to stop eating. It is secreted by fat tissue cells and binds to receptors in the brain. If the body is secreting too much leptin though, a condition called leptin resistance can develop. The brain will begin to stop responding to leptin and then doesn’t receive the signal to stop eating. Since leptin is secreted by fat tissue cells, obese individuals usually develop leptin resistance which is why they tend to overeat.


They began research for this study by testing mice with leptin production. In this study, the researchers found that an enzyme called HDAC5 plays a current role in the leptin pathway. The mice with high levels of this enzyme did not gain as much weight as mice with the low levels of this enzyme. More research is needed, but researchers believe that enzymes in the body have an effect on over-eating.


The conclusion of the article states that in addition to a healthy diet and regular exercise, in the future the components of this study may contribute to the development of potential weight loss drugs. However, the researchers stated that there is not clear evidence that the enzyme will be a suitable target in humans the same way it was in the mice.

Article Critique

Sarah G Miller, a graduate from the University of Pennsylvania, is a current Staff Writer for LiveScience.Com. She writes daily stories on breaking scientific news with a focus on health and medicine. She has also worked as a Medical Researcher and wrote articles for major publications such as The Oprah Magazine, AARP magazine, and Healthy Magazine (UK). I think the author could be a credible source of information because she does have some background experience working as a medical researcher. I also think that she has more experience working as a journalist rather than actually researching. I think if this article was produced by a medical researcher or a scientist it would be more credible. If she would’ve posted her source on how she got her research information it would make the article more credible also. I think you could trust the author more if the article was written by an institution, doctor, university, or other scholarly source.


I think the source of the article isn’t extremely credible. It is a website called “LiveScience” that is a website that publically writes daily articles about topics such as health, space, animals, and other science topics. If the website was specifically about nutritional topics that would make it more credible. I think the fact that the website is a .com website does not make it a credible source either. A journal, scholarly article, or .edu website would be more credible than this website. This website does not give sources on where their information and research comes from, so it is not considered a credible website to use.


I do not think the information in the article is credible enough for it to be used as research. The article talked about many points on how hormones and enzymes could affect overeating but the researched was not supported but much evidence. The author stated repeatedly “more research is needed” or “not known”. I think the article just summarized how there could potentially be more research and studying done on this topic but never fully stated factual evidence. The article stated the basic background about the hormones and enzymes and how they worked in the body, but the article could not connect how that could relate to potential for people who overeat.