Marfan syndrome

By Jordan Laufenberg


Marfan syndrome is a defect in the gene that tells the body how to make fibrilin-1 (a protein that is important in connective tissue) which results in an increase of the protein called transforming growth factor beta or TGFB. TGFB causes problems in tissue in the body which could create different Marfan syndrome features and cause medical problems.


There are many different treatments that depend on the systems that are affected. Systems that can be affected are:

  • Bones and joints
  • Eyes
  • Heart and blood vessels
  • Nervous system
  • Lungs
  • Physical activity and exercise
The treatments for these systems minimize the medical problems but do not get rid of them completely.