He did paintings and sculptures, his most famous works are the painting on the ceiling of the Sistine Chapel, the sculpture David, currently at Galleria dell'Accademia in Florence, Italy, the sculpture Pietá, at Basilica di San Pietro in Vaticano, and The Creation of Adam, a part of a series on the Sistine Chapel ceiling, Vatican City. His patrons were Lorenzo de' Medici, Pope Leo X, Pope Paul III who he also did work for.
This is a large painting on the entire ceiling in the chapel which hundreds of people to go see everyday. It was painted with Artistic work type of fresco (painting on a wall). What is interesting about this piece are the children next to his shoulder, what book he is reading, and why the pages are gold. He sat on a ladder for twelve hours a day painting on the large ceiling.
This painting represents humanism because the prophet Isaiah is depicted to look like a human being and the children are depicted to also look like human children.