Duncan's Disease

Emma Jowdy and Erin Mingey

Duncan's Disease

It is a disorder of the immune system where it weakens and can't fight viruses and bacteria to protect our body; tissues, proteins, and organs don't work together properly.

Symoptoms

-impaired/enlarged liver function

-enlarged spleen

-sore throat

-fever

The protein that has been effected is called SAP. This protein is suppose to regulate how many white blood cells attack viruses. When a mutation is made to the specific gene less SAP is produced meaning more white blood cells are dying because they aren't being regulated.

Inheritance Pattern

Duncan's Disease is a sex-linked disorder, meaning that it is passed down on the X and Y chromosomes.
Big image

Other Names

There are many other names for this disease:

-X-linked lymphoproliferative disease (XLP)

-Familial Epstein-Barr infection

-Purtilo Syndrome

-Severe susceptibility to EBV infection

-Severe susceptibility to infectious mononucleosis

Treatment

The recommended treatment for a patient who has XLP and has to wait for a bone marrow transplant with a suitable donor is a high dose of methylprednisolone and VP-16 for 15 months.

Works Cited


"Symptoms of X-linked lymphoproliferative syndrome." The Right Diagnosis. Health
Grades, 17 Apr. 2015. Web. 3 May 2015. <http://www.rightdiagnosis.com/x/
x_linked_lymphoproliferative_syndrome/symptoms.htm>.

"X-linked Lymphoproliferative Disease." Genetics Home Reference. U.S. National

Library of Medicine, Nov. 2014. Web. 3 May 2015. <http://ghr.nlm.nih.gov/
condition/x-linked-lymphoproliferative-disease#synonyms>.


Zelley, Kristin, ed. "X-linked Lymphoproliferative Syndrome." The Children's
Hospital of Philedelphia. N.p., 3 Sept. 2012. Web. 3 May 2015.
<http://www.chop.edu/conditions-diseases/
x-linked-lymphoproliferative-syndrome#.VUa9Utq9KK1>.