Marburg Virus

By: Brandon Wiesinger

Family and Genus of the Marburg Virus

Genus: Marburgvirus

Family: Filoviridae

Why: Uses virion to infect its host, negative strand of linear genome, infects through zoonosis and body fluids.

Diseases Caused:

Hemorrhagic Fever
Causes patient to have large amount of bleeding inside and outside of the body, patient usually dies within 8 to 9 days after these symptoms onset due to large amounts of blood loss and shock.

Proteins, Nucleic acids:

Glycoprotein: Helps the virion attach to the cell.

Nucleoprotein: encapsidate the virus genome for the purposes of RNA transcription, replication and packaging.

VP24: function has not been found out yet.

Matrix VP24: function has not been found out yet.

Polymerase: caps mRNAs and polyadenylates them during synthesis.

Transcription factor VP30: transcription antitermination factor right after transcription has initiated.

Polymerase cofactor VP35: inhibits interferons production and cofactor of viral RNA polymerase.

Groups of organisms and body systems infected:

Infects: Bats, humans and primates

Affects the body's vascular system, affects how blood moves through the body, causes internal and external bleeding and also organ failure.

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Diagrams of infection in the cell and transmission host to host

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Symptoms of Virus:

  • High fever
  • Severe headache
  • Sever malaise
  • Watery diarrhea
  • Cramping
  • Vomiting
  • Nausea
  • Hemorrhagic fever
  • Bleeding internal and external
  • Sustained high fever
The virus attacks the vascular system. It drains body of nutrients and water through vomiting and diarrhea. Then causes severe blood loss which often results in death.

Cure and Prevention:

No cure or vaccine right now. Research is still in progress. To help the patient live, IVs or other means of hydration are necessary for survival.


Prevention

Make sure pigs on pig farms in Africa aren't infected by the fruit bat. Certain fruit bats are carriers of the disease. Raise awareness on how the virus is spread and what causes infection. Also, teach communities how to deal with treating dead bodies and patients with the disease.

Bibliography

"ViralZone: Marburgvirus." ViralZone: Marburgvirus. Web. 21 Mar. 2016.


"Marburg Haemorrhagic Fever." World Health Organization. Nov. 2012. Web. 21 Mar. 2016.


"Ugandan Health Worker Dies Of Marburg Virus, Ebola Relative." Forbes. Forbes Magazine. Web. 21 Mar. 2016.(Used for the picture)


Basler, Christopher F. "Filovirus Pathogenesis and Immune Evasion: Insights from Ebola Virus and Marburg Virus." Nature.com. Nature Publishing Group, 6 Oct. 2015. Web. 21 Mar. 2016.(Used for the picture)


"Ebola and Marburg Virus Disease Epidemics: Preparedness, Alert, Control, and Evaluation." Www.who.int/en/. WHO. Web. 21 Mar. 2016.(used for diagram)