2003 Chemistry Nobel Prize Winners

William Lord, Serena Kana, Teja Kommera

Peter Agre

  • Received a "D" in his Chemistry class in high school
  • Is also a cross country skier
  • Was an Eagle Scout

Fun Facts:

  • Studied Biomedical Sciences and Engineering
  • Was a professor at the Johns Hopkins School of Public Health
  • Attended both Augsburg College and the Hopkins School of Medicine in Baltimore
  • Has not died yet
  • Born in Northfield, Minnesota
  • Born January 30, 1949

Robert MacKinnon

  • Born on February 19, 1956
  • Born in Burlington, Massachusetts
  • Has not died yet
  • Attended both Brandeis University and University of Massachusetts Boston
  • Was the head of the Laboratory of Molecular Neurobiology and Biophysics
  • Studied Neurobiology and Biophysics

Fun Facts

  • Wrote a book teaching people how to speak Gaelic

What did they do?

  • Agre discovered Aquaporin
  • Agre's First experiment: put unfamiliar protein in distilled water and it exploded like popcorn ---> realized it associate with water
  • Agre discovered how cells function with water channels
  • He also discovered how to isolate the membrane
  • Discoveries led to studies of water channels in biochemical and genetics areas
  • MacKinnon further discovered structural studies of ion channels
  • He discovered how to "see" ions flowing through channels
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Result of work

  • These discoveries provided new insights to mechanisms in living organisms
  • Could potentially solve medical problems like fluid retention in heart disease
  • Aquaporin plays a key role in a type of diabetes that creases urine reduction
  • Has led to more in-depth studies in particular areas
  • Ion channels can help us with our nervous and muscular system

Why They Won

  • introduced the ways in which proteins move throughout cells
  • contributed to the cures of many diseases throughout the body
  • led to major developments in the understanding of the human body
  • now we know how and why ions travel through the cell
  • their research contributed to better and more effective medicines

Future Impact

  • Currently this research is being used for developing more effective medicines
  • more innovations will expand upon these discoveries to make faster working medicines
  • medicines will be able to better take advantage of transportation throughout the human body
  • greater understanding of how things are transported throughout a cell