A rare diseaese
What is Progeria?
Symptoms of Progeria
Symptoms start showing when the child is around 18-24 months old. Symptoms may include:
- Aged looking skin
- Small face and jaw relative to head
- Prominent veins all over the body
- Stiff joints
- Profound failure to thrive in first year of life
- Hip dislocation
- Receding mandible
- Narrow nasal bridge
- Loss of subcutaneous fat
- Severe progressive cardiovascular disease
- Pinched nose
- Decayed teeth or no formation of teeth
Who is affected by Progeria?
- It is estimated that 100-200 people in the world have Progeria. There are most likely many cases that aren't reported or the children are killed.
- About 1 in 8 million people get Progeria
What causes Progeria?
- To slow heart disease some have undergone coronary bypass surgery and/or angioplasty to reduce the risk of cardiovascular problems cause by progressive heart disease.
How Does Progeria Affect The Body?
- Small frame
- Thin bones
- Susceptible to getting arthritis
X-Ray of Progeria Patient
A: Healthy skull with normal mandible
B: Skull with Progeria, mandible is receding
C: Clavical when healthy
D: Clavical with Progeria becoming deformed
E: Clavical still healthy slightly disformed
F: Clavical has progressive resorption
G: Ribs that are healthy and have normal morphology
H: Ribs with Progeria are very thin, person has a pacemaker
Cardiac manifestations: angina, congestive heart failure
- Stroke, and silent strokes that are seen on MRI or CT of the head
Effect of Progeria on the Integumentary System
Person with Progeria
- Prominent veins over most of body
- Loss of hair
- Prominent eyes
- Lack of ear lobes, in some but not all cases
- Loss of eyebrows and sometimes eyelashes
- Unhealthy fingernails and toenails
- Some have the inability to fully close the eye
- Thin lips
- The epidermis protects the inside of the body from the outside world
- Skin is moisturized
- The epidermis is waterproof and has elasticity
- Hair to protect from the Sun
- Subcutaneous fat provides a layer of cushion between skin and the muscles, bones, and organs
- Hair is present on almost all of the body
Night of Wonder
Saturday, April 12th, 10pm-12am
Cambridge, MA, United States
"About Progeria." Progeria Research Foundation. Progeria Research Foundation, n.d. Web. 19 Nov. 2013.
Board, A.D.A.M. Editorial. "Progeria." Progeria. U.S. National Library of Medicine, 08 Apr. 2011. Web. 19 Nov. 2013.
Gordon, Leslie B., W. Ted Brown, and Francis S. Collins. "Hutchinson-Gilford Progeria Syndrome." NCBI. U.S. National Library of Medicine, n.d. Web. 22 Nov. 2013.
"Hutchinson-Gilford Progeria Syndrome." Genetics Home Reference. N.p., n.d. Web. 19 Nov. 2013.
"Learning About Progeria." Learning About Progeria. N.p., n.d. Web. 25 Nov. 2013.
N.d. Photograph. Disease Progression in Hutchinson-Gilford Progeria Syndrome: Impact on Growth and Development. Web. 2 Dec. 2013.
N.d. Photograph. Family Takes on Progeria in 'Life According to Sam' Web. 4 Dec. 2013.
N.d. Photograph. Hayley Okines: There's a Lot to Be Positive about. Web. 9 Dec. 2013.
N.d. Photograph. Http://www.theblaze.com/stories/2012/09/25/you-wont-believe-what-firefighters-across-the-country-did-for-a-4-year-old-with-cancer/. Web. 11 Dec. 2013.
N.d. Photograph. Rochelle, the Girl Who Is 80 Years Old. Web. 17 Dec. 2013.
N.d. Photograph. South Africa Observes New Case of Progeria. Web. 6 Dec. 2013.
N.d. Photograph. Web. 9 Dec. 2013.
"Progeria 101/FAQ." Progeria Research Foundation. Progeria Research Foundation, n.d. Web. 26 Nov. 2013.
Saey, Tina Hesman. "Rare Disease Sets Mom's Research Agenda." Science News 23 Feb. 2013: n. pag. Print.