Structure-based drug design - the hidden tracks
the hidden tracks
Adjusting torsions, finding new interactions, filling voids or displacing water molecules are all familiar concepts. But who knows about dehydrons? Who uses B-factors and who has ever thought about the mathematics of IC50 values? Magic methyls sometimes magically appear, but who takes control of the magic wand? Let's get started in some of the hidden tracks of the world of structure-based drug design.
Each section comprises a presentation, demonstration on internal data and a break-out session