Elizabeth Eggers Katie Fournier Tonya Hensley Jessica Sipes
It is a highly potent broad spectrum Antibiotic used to treat life-threatening infections.
- Children: Neonates have an increased risk of neuromuscular blockade; difficulty in assessing auditory and vestibular function and immature renal function. Individualize the dose.
- Older Adults: Difficulty in assessing auditory and vestibular function and age related renal impairment. Need to monitor renal function and individualize the dose.
- Renal Impairment: May need to decrease the dose with blood level monitoring to prevent toxicity. With a urinary tract infection smaller doses can be used.
- Hepatic Impairment: Use gentamicin and no adjustments in dosage or frequency indicated but monitor the plasma concentrations.
- Critical Illness: At risk for developing nephrotoxicity and ototoxicity follow guidelines strictly. Preferred to use in combination with other antibacterial agents. Once the identified organism is known then a discontinuation of the aminoglycoside takes place and a less toxic antibiotic is the prescribed.
- Home Care: Administration of gentamicin does not typically occur in the home. Instruction of IV care is essential for caregivers who are giving medication.
· Renal toxicity
· Auditory loss of inner ear
· Neuromuscular blocker
· Decreased appetite
· Increased thirst
· Muscle twitching/seizures
· Vomiting and Nausea
· Urine output changes
· Allergic reactions
· Necrosis of liver
· Interfere with neuromuscular transmission
· Irreversible hearing loss
Observe for an infection and the reaction of the antibiotic on the microorganisms.
Other Drugs in Class: