Pathogen - Yersinia pestis
Plague has given rise to at least three major pandemics. The first (“the Justinian plague”) spread around the Mediterranean Sea in the 6th century AD, the second (“the Black Death”) started in Europe in the 14th century and recurred intermittently for more than 300 years, and the third started in China during the middle of the 19th century and spread throughout the world. This casued millions of death and a widespread of religious fears.
Over the last 20 years, there have been 1,000 to 5,000 human cases of plague and 100 to 200 deaths reported to the World Health Organization. This is a re-occurring disease and is a threat in Africa right now, but originally came back in Asia.