- short stature
- ages appearance usually begins at the age of 20
-graying and loss of hair
- hoarse voice
- thin hardened skin
- facial appearance described as "bird-like"
- thin arms and legs
-thick trunk due to abnormal fat disposition
-can lead to cancer
Inheritance disease pattern
Werner syndrome is a autosomal recessive patter, both copies of the WRN gene in each cell is mutated. The parents of the affected person each Carrie one copy of the mutated gene, but usually they don't show signs and symptoms of the disorder.The Werner protein helps copy DNA when the cells are preparing to divide. When the gene has a mutation, the Warner protein is short and does not function normally.