Werner syndrome

Crystal Rivas


-people with the disorder grow and develop normally until puberty

- short stature

- ages appearance usually begins at the age of 20

-graying and loss of hair

- hoarse voice

- thin hardened skin

- facial appearance described as "bird-like"

- thin arms and legs

-thick trunk due to abnormal fat disposition

-can lead to cancer

Inheritance disease pattern

Werner syndrome is a autosomal recessive patter, both copies of the WRN gene in each cell is mutated. The parents of the affected person each Carrie one copy of the mutated gene, but usually they don't show signs and symptoms of the disorder.The Werner protein helps copy DNA when the cells are preparing to divide. When the gene has a mutation, the Warner protein is short and does not function normally.

Person with Werner Syndrome

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Interesting Facts

Werner syndrome is considered to be very rare. It is estimated that one in 200,000 people in the United States may have Werner syndrome. Werner syndrome is somewhat more common in Japan, where it is estimated that one in 30,000 people may have the condition. This is because a genetic mutation was known to occur many generations ago, when Japan’s population was smaller in number, and over time the mutation has been passed down repeatedly, affecting a higher number of people; this is called a founder mutation.


There is no specific treatment for Werner syndrome. The symptoms of each individual case are treated to improve quality of life and lengthen the lifespan of someone with the condition. Treatments for each symptom can involve medications or surgical intervention. These treatments are more effective when a person is diagnosed early so that medical care providers can recommend preventive measures and screen for cancers and other diseases associated with this condition.

Work cited

-Zaykoski, Leigh A., ed. "Treatment of Werner Syndrome." Bright Hub. N.p., 26 Sept. 2009. Web. 4 May 2015. <http://www.brighthub.com/science/genetics/ .

-Genetic Home Reference. N.p., Dec. 2012. Web. 4 May 2015.