- Huntington is an autosomal dominant disorder for only one copy of the defective gene, inherited from one parent, is necessary to produce the disease.
- Huntington's disease is located on chromosome 4.
- Huntington's typically begins-midlife, between the ages of 30-50. Onset though may occur as early as age 2.
- The higher the CAG repeat the more likely HD will strike at a younger age. Though most individuals that inherit HD exhibit symptoms between the ages of 30-50, typically middle age. Though there are rare cases for children as young as 2 and as old as 80 to exhibit symptoms of HD.
- The affected person of Huntington's usually inherits the altered gene from one affected parents.
More on Huntington's
- Taking a sample of fluid around the fetus (amniocentesis)
- Taking a sample of fetal cells from the placenta (chronic villus sampling (CVS))
A gene test, done by inspecting blood, is available which allows a person to find out if they carry the abnormal HD gene and will someday develop the disease.
Huntington's disease has a penetrance of 100% because all persons who inherit the expansion mutation in their gene coding for Huntington's disease, become ill with the disease.
- A trinucleotide repeat (CAG) expansion in the huntingtin gene causes Huntington's disease (HD). The increased size of mutant huntingtin correlates with the CAG repeat expansion. The bigger the CAG repeat the earlier the onset.
Some movement disorders include:
- Involuntary jerking or writhing movements
- Muscle rigidity
- Slow, uncoordinated fine movements
- Difficulty with the physical production of speech
- Inability to start a task or conversation
- Difficulty planning, organizing and prioritizing tasks
- Difficulty focusing on a task for long periods
- Lack of awareness from one's own behaviors and abilities
- Social withdrawal
- Changes in appetite
- Insomnia or excessive sleeping
- Behavior problems
- Tremors or slightly involuntary movements
- Changes in fine motor skills
- Medications for movement disorders include, Tetrabenazine, antipsychotic drugs, and other to suppress movements, muscle rigidity, and chorea.
- Medications for psychotic disorders include antidepressants, antipsychotic drugs, and mood stabilizing drugs
- There is also therapy to help behavior problems, coping strategies, and mange exceptions such as speech therapy, physical therapy, and occupational therapy.
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"Huntington's Chorea." Home Page. N.p., n.d. Web. 25 Nov. 2013. <http://cirrie.buffalo.edu/encyclopedia/en/article/357/>.
"Huntington's Disease Center of Excellence at USF." N.p., n.d. Web. 22 Nov. 2013. <http://health.usf.edu/medicine/neurology/hdcenter/index.htm>.
"Huntington's Disease: Hope Through Research." National Institute of Neurological Disorders and Stroke (NINDS). N.p., n.d. Web. 21 Nov. 2013. <http://www.ninds.nih.gov/disorders/huntington/detail_huntington.htm>.
Staff, Mayo. "Definition." Mayo Clinic. Mayo Foundation for Medical Education and Research, 5 May 2011. Web. 21 Nov. 2013. <http://www.mayoclinic.com/health/huntingtons-disease/DS00401>.
"Modules." — DRZE. N.p., n.d. Web. 22 Nov. 2013. <http://www.drze.de/in-focus/predictive-genetic-testing/modules?set_language=en&search_letter=p>.
"What Causes Huntington's Disease?." Home. N.p., n.d. Web. 22 Nov. 2013. <http://www.uabmedicine.org/conditions-and-services/neuro-movement-huntingtons-disease>."What Causes Huntington's Disease?." Home. N.p., n.d. Web. 22 Nov. 2013.>.