Wade Wilson was given an experimental treatment to cure his cancer and now has extreme regeneration as well as somehow getting a sword that stops regeneration. He made the alter ego Deadpool and constantly breaks the fourth wall and is evil because he killed Wolverine. He is immune to disease.
Slade Joseph Wilson also known as Deathstroke is an overpowered assassin who is a master tactician and at the peak physical and metal state. In an accident involving his son losing his vocal cords and his wife attacking him, then losing his eye, Slade became slightly twisted and then became an even deadly assassin and super villain.