Zosyn (Piperacillin/ Tazobactam)

By: Jacqueline Coronado

What is Zosyn?

Zosyn is a combination of piperacillin and tazobactam that is prescribed by your doctor and is used to treat infections. Zosyn can be given to those who are suffering from appendicitis to help with the healing process and the prevention of a bacterial infection. This anti-bacterial drug is normally given after surgery to prevent wound infections and it is given through an injection into the vein.
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Is Zosyn Right for You?

Zosyn is given to those fighting an infection right after surgery, it is very common for patients suffering from appendicitis to receive this antibacterial injection.

But how do I know if Zosyn is right for me? Before taking Zosyn, you should tell your doctor if you have or have ever had:

  • Asthma
  • Kidney disease
  • Liver disease
  • Bleeding or blood cutting disorder
  • Allergies (especially for any certain drugs)
  • Cystic fibrosis
  • Gastrointestinal disease (especially colitis)
  • Pregnant

Warning and Side Effects


  • Allergies to penicillin, cephalosporins, imipenem
  • Risk of bleeding complications
  • Risk of seizures
  • Increase frequency of fever and rashes on patients suffering from Cystic fibrosis
  • Prolong used may result in bacterial or fungal superinfection

Side Effects:

  • Nausea or vomiting
  • Constipation or diarrhea
  • Gas
  • Insomnia
  • Headaches

If you experience any of the serious following side effects, stop using Zosyn and call your doctor immediately:

  • Shortness of breath
  • Rashes or itchy skin
  • Rapid heart rate
  • Swelling
  • Unusual bleeding
  • Seizures
  • Developing flu-like symptoms

How is Zosyn Taken?

Zosyn is given through an injection in the vein and is given by your doctor or nurse. Do not give yourself the medicine if you are not aware of how to properly inject oneself or dispose of or handling needles.


Zosyn is given 3.375g every 6 hours for 7-10 days and is administered by intravenous infusion over 30 minutes.


Patients 9 months or older, weighing up to 40kg, is recommended to be given 100mg per kilogram of body weight every 8 hours. Patients 2-9 months should be given 80kg per kilogram of body weight every 8 hours. Pediatric patients weighing over 40kg should receive adult doses.

Ask or consult with your doctor to see if Zosyn is right for you.