Leukemia Genetic Disorder

By: Parker Dunham

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Picture Citation

"Chronic Myelogenous Leukemia Treatment." National Cancer Institute. N.p., n.d. Web. 09 Dec. 2015

Leukemia Chromosome

Leukemia is a trans-location between chromosomes 9 and 22. This means that the bottoms of chromosomes 9 and 22 swap places. When chromosomes mutate it messes up the whole strand of DNA which can cause abnormal changes. For leukemia it causes your cells to grow and divide rapidly which crowds out the healthy blood cells in a persons bone marrow.


"Leukemia." Causes. Mayo Clinic, n.d. Web. 07 Dec. 2015.

Leukemia Name and Symptoms/Complications

The full name of the Leukemia gene is Promyelocytic Leukemia. There are many symptoms and complications that come with leukemia. A few symptoms are fever or chills, weakness, bone pain or tenderness etc. There are many complications, some are, excess bleeding, bone/joint pain, etc.


· "PML Gene." Genetics Home Reference. N.p., n.d. Web. 07 Dec. 2015.

· "Chronic Myelogenous Leukemia." Complications. Mayo Health Clinic, n.d. Web. 07 Dec. 2015.

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Wikipedia. Wikimedia Foundation, n.d. Web. 09 Dec. 2015.

Type of Mutation

The leukemia type, familial acute myeloid leukemia is dominant autosomal. This means that one copy of the mutation is enough to cause the disease because it is a dominant allele. Leukemia is a mutation, not inherited, meaning that it cannot be passed down through families.


"Familial Acute Myeloid Leukemia with Mutated CEBPA." Genetics Home Reference. N.p., n.d. Web. 07 Dec. 2015.

Detecting The Leukemia Gene

Leukemia is detected in the blood and bone marrow. Symptoms can be used to detect the disorder but they are often vague, and even if you don't suffer from the symptoms of leukemia you may still be carrying the gene. Many tests are required to diagnose Leukemia, including primarily blood work, bone marrow and lumbar puncture tests. A lumbar puncture is a test where a small needle is poked in a special place in your back and a fluid is acquired and then the doctors look for leukemia cells in the fluid.


"How Is Chronic Myeloid Leukemia Diagnosed?" How Is Chronic Myeloid Leukemia Diagnosed? American Cancer Society, n.d. Web. 09 Dec. 2015.

"How Is Acute Lymphocytic Leukemia Found?" How Is Acute Lymphocytic Leukemia Found? Cancer.org, n.d. Web. 13 Dec. 2015.


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University of Utah Health Care, n.d. Web. 09 Dec. 2015

Leukemia Treatments

The most current common treatments for leukemia are chemotherapy and biological therapy, Chemotherapy is a drug used to kill leukemia cells and biological therapy helps the immune system attack leukemia cells. There are also many more available treatments. Currently there is only treatment and care but there is not a known cure.

Current Leukemia Research

Doctors are currently working on new ways to prevent, treat and create a possible cure for leukemia. Researchers are also studying specific genes and mutations to see if they can trigger the leukemia for possible treatments or cures. They think this will be achieved through new drugs. The treatment drug "Mepolizumab" is also being studied as early studies have shown that it can reduce the number of eosinophils for people with allergies human embryonic stem cells (HES). HES's are cells that come from the human embryo. Eosinophils are basically white blood cells that contain bits of Eosin stained particles. Eosin is a red substance that stains easily and can damage your white blood cells.


"Leukemia - Eosinophilic - Latest Research." Cancer.Net. N.p., 25 June 2012. Web. 08 Dec. 2015.

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Picture Citation

"Leukemia Research." Leukemia Research. N.p., n.d. Web.

More Information

For more information go to

  • Search Leukemia- Mayo Health Clinic
  • Search Leukemia- Cancer.Net

Interesting Facts

  • Approximately every 4 minutes, someone in the United States is diagnosed with a type of blood cancer.
  • Leukemia is the 10th most frequently occurring type of cancer in all races or ethnicities.

Help Put an End

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Wear Orange To Raise Awareness!

Sources

"Leukemia." Causes. Mayo Clinic, n.d. Web. 07 Dec. 2015.

"PML Gene." Genetics Home Reference. N.p., n.d. Web. 07 Dec. 2015.

"Chronic Myelogenous Leukemia." Complications. Mayo Health Clinic, n.d. Web. 07 Dec. 2015.

"Familial Acute Myeloid Leukemia with Mutated CEBPA." Genetics Home Reference. N.p., n.d. Web. 07 Dec. 2015.

"Leukemia - Eosinophilic - Latest Research." Cancer.Net. N.p., 25 June 2012. Web. 08 Dec. 2015.

Places to go for more info- Mayo health clinic, and Cancer.Net.