Triple X Syndrome

Trisomy X or 47,xxxx

Description of Disorder

This is caused by an additional X chromosome in each of a females cells, having 47 instead of 46. This increases risks of learning disabilities and delayed development of speech and language skills.

Genetic Cause:

Most cases are actually not inherited, because it is a random event during the formation of reproductive cells. An error in cell division called "nondisjunction" which is when homologous chromosomes fail to separate properly during cell division.


An extra copy can be associated with a tall stature and Increased risk of learning disabilities.

  • Delayed development of speech and language skills
  • Delayed development of motor skills, like sitting and walking.
  • More prone to anxiety, behavior, emotional problems.


A chromosome error such as this one cannot be repaired, the syndrome itself has no cure. The treatment is based on symptoms and needs with that particular individual diagnosed. Options that may be helpful are:

  1. Early Intervention services ( Speech occupational, physical or development therapy).
  2. Educational assistance
  3. Supportive environment and counseling.

NORD ( National Organization for Rare Disorders )

NORD is a supportive group in which is a non-profit organization aiming to provide support individuals with rare diseases by advocating and funding research, education, and networking aiming service providers. Normally, females have two X chromosomes so Trisomy X carry 3 X chromosomes in the nuclei of body cells. This disorder occurs in 900 to 1,000 live births. Some may have zero symptoms, others very mild, or more complex.
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