Famous Scientist: Karl Paul Link
Jocelin Loewen Chemistry 4th
Contributions to Science
Experiment 1
Experiment 2
In another experiment, with the help of his students, Link continued to search for the hemorrhagic agent. In four months, they were able to isolate 1.8 grams of recrystallized anticoagulant, which gave them enough information to check it against their last experiment. This allowed them to thoroughly characterize the agent. They did some degradation experiments, and found out that the anticoagulant was 3,3′-methylenebis-(4-hydroxycoumarin) which was later renamed dicumarol.
Sources Cited:
http://scifun.chem.wisc.edu/wisidea/wisidea.htm
http://www.nap.edu/openbook.php?record_id=4548&page=176
http://www.jbc.org/content/280/8/e5.full?sid=d2687f36-93cb-4cf8-8992-74403a6e4855
http://www.wisegeek.com/what-is-coagulation.htm#blood-composition-diagram
http://objects3d.storage.googleapis.com/49alYdNfRtd/2d/poster-0.jpg
http://www.pathology.vcu.edu/clinical/coag/PT%20INR.pdf