Progeria Project: Nathan Rubin

Learn all about Progeria in this presentation!

What is Progeria?

A progressive genetic disorder that causes children to age rapidly. When this happens, children affected by the disease age almost 8 times faster than a normal person, which causes them to have an elderly person's body within the first years of life. Sometimes this is also called Hutchinson-Gilford Syndrome (HGPS)

How Is Progeria Passed From One Generation To The Next?

With progeria, many children only live to a young age, so they are not able to pass on the disease, plus, one of the symptoms of progeria is that they do not fully sexually mature, so even if they did live long enough, they probably wouldn't be able to reproduce. Progeria occurs because of a genetic mutation in the DNA.

Some Pictures Of Progeria...

*Note: Progeria Is a Dominant Gene and Is Associated With A "Misspelling" On Chromosome One*

Symptoms Of Progeria

There is a large variety of symtoms that come with progeria, including a short stature, slow growth, underdeveloped jaw, skin wrinkles/dryness, hair loss, delayed tooth development, enlarged head, hearing loss, high-pitched voice, incomplete sexual maturation, joint stiffness, loss of muscle, osteoarthritis, and taut skin

Progeria Prognosis

Life Expectancy: 13-15 Years Old (108-124 year-old body)


Quality Of Life: The quality of life for children with progeria isn't miserable, but it is pretty bad. Children that are not even very old have the same qualities as an elderly person, so they have trouble doing day-to-day physical activity and other things, but some kids affected with the disease have a very positive outlook and do whatever they can to have the best life possible.


Outlook On The Future: Children with progeria don't have much of a future because they usually die at a very young age, which means missing important things in life that most other people get to do. Many children are aware of this but still maintain a positive attitude and do as much as they are able to do.

Possible Treatments For Progeria


Prescription

Statin: Pravastatin (Pravachol), Simvastatin (Zocor), Atorvastatin (Lipitor)

Other treatments: Zoledronic acid by injection (Zometa)


Self-treatment

Anti-inflammatory: Aspirin


Also common

Devices: Hearing aid

Procedures: Dental extraction

Therapies: Occupational therapy, Physical therapy

How Is Progeria Diagnosed? How Common Is It?

Diagnosing The Disease: There is now a test used by doctors to examine and assess if someone is affected, but since recently doctors had to diagnose children based purely on evidence based on whether they have the symptoms.


Rarity: This disease is extremely rare, and fewer than 1,000 cases are recorded each year. Just over 100 known cases are present in the world as of 2016.


Note: This disease is not more common regardless the group of people