Cystic Fibrosis

Cause of Cystic Frbrosis

Mutations in the CFTR gene cause cystic fibrosis. The CFTR gene provides instructions for making a channel that transports negatively charged particles called chloride ions into and out of cells.

How is it inherited?

The child receives one of his chromosome 7's from fathers sperm, and one from mothers egg. If both of these chromosomes have a mutated CFTR gene then the kid will have CF.

Will your next child have CF?

It is possible that your next child will not have CF. But if you have CF and your spouse is a carrier of CF then the chances are higher.
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What ethnic group is it most prevalent in?

Cystic fibrosis is a common genetic disease within the Caucasian (white) population in the United States. The disease occurs in 1 in 2,500 to 3,500 Caucasian newborns.

Symptoms of Cystic Fibrosis



  • Progressive Damage to the respiratory system
  • Chronic Digestive system problems
  • Chronic coughing
  • Wheezing
  • Inflammation
  • very salty-tasting skin
  • poor growth/weight gain


Over time, mucus buildup and infections result in permanent lung damage, including the formation of scar tissue (fibrosis) and cysts in the lungs.


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When will you know if your child has CF?

70 % of patients are diagnosed with CF by age 2

Life Expectancy of a child with CF

The predicted range of survival is late 30s

Treatment

  • Clearing the airway
  • antibiotics
  • implanted devices
  • nutrition and eating right