Sickle Cell Disease
single gene mutation
Sickle cell disease was discovered in 1910 by Dr. James B. Herrick
Dr. james .B. Herrick
Sickle Cell Disease is a genetic disorder that alters the shape of red blood cells.
difference between sickle red blood cells and red blood cells
what the disease is named after
a sickle is a short-handled farming tool with a semicircular blade, used for cutting grain
sickle red blood cells and red blood cells in the vain
impact on life expectancy
an individual with this disease can expect to live into there forties or fifties
- pain and swelling in the hands and feet
- yellowed skin
- pale skin
- chest pain or episodic pain in joints abdomen and back
- shortness of breath
- abdominal swelling
- unusual prolonged headache any sudden weakness or loss of sensation
- Destruction of spleen
- severe bacterial infections
- kidney and bone infection
- damage to joints, especially hip and shoulder
- gall stone
- damage to eye resulting in impaired vision
- stroke or other neurological impairment
- liver disease
- High rate of Hepatitis c
- hurt murmurs or enlarged heart
how do people inherit sickle cell disease
- this disorder occurs in people of African american sub-Saharan and of Greek decent
- sickle cell disease is a recessive trait
- it occurs on chromosome eleven
- 1 out of every 500 African american children is born with sickle cell
diagram of howsickle cell disease is inherited
test performed to determine if an individual has this disease
doctors can perform a hemoglobin electrophoresis blood test to determine if a person has this disease
how to prevent this disease
- to prevent infractions babies and children must take a daily dose of penicillen.
- patients also take folic acid to build new red blood cells.
- people with more severe cases can have bone marrow transplants.
- also blood transfusions can be performed to provide new red blood cells.
- Doctors recommend drinking plenty of water, sleeping,and to avoid to much physical activity.
- American sickle cell anemia foundation
- sickle cell disease association of america
- children's sickle cell foundation
- sickle cell society