Sickle Cell Disease

single gene mutation


Sickle cell disease was discovered in 1910 by Dr. James B. Herrick

Dr. james .B. Herrick

Big image


Sickle Cell Disease is a genetic disorder that alters the shape of red blood cells.

impact on life expectancy

an individual with this disease can expect to live into there forties or fifties


  • pain and swelling in the hands and feet
  • fever
  • yellowed skin
  • pale skin
  • chest pain or episodic pain in joints abdomen and back
  • shortness of breath
  • fatigue
  • abdominal swelling
  • unusual prolonged headache any sudden weakness or loss of sensation


  • Destruction of spleen
  • severe bacterial infections
  • pneumonia
  • Meningitis
  • kidney and bone infection
  • damage to joints, especially hip and shoulder
  • gall stone
  • damage to eye resulting in impaired vision
  • stroke or other neurological impairment
  • seizures
  • liver disease
  • High rate of Hepatitis c
  • hurt murmurs or enlarged heart

how do people inherit sickle cell disease

  1. this disorder occurs in people of African american sub-Saharan and of Greek decent
  2. sickle cell disease is a recessive trait
  3. it occurs on chromosome eleven
  4. 1 out of every 500 African american children is born with sickle cell

diagram of howsickle cell disease is inherited

Big image

test performed to determine if an individual has this disease

doctors can perform a hemoglobin electrophoresis blood test to determine if a person has this disease

how to prevent this disease

  • to prevent infractions babies and children must take a daily dose of penicillen.
  • patients also take folic acid to build new red blood cells.
  • people with more severe cases can have bone marrow transplants.
  • also blood transfusions can be performed to provide new red blood cells.
  • Doctors recommend drinking plenty of water, sleeping,and to avoid to much physical activity.

support groups

  1. American sickle cell anemia foundation
  2. sickle cell disease association of america
  3. children's sickle cell foundation
  4. sickle cell society

American sickle cell anemia foundation logo

Big image