Color Mutations in Dobermans
Color Dilution Alopecia Genetic Skin Condition in Dogs
This disease can be seen in a variety of canine breeds including doberman pinschers, Irish setters, dachshunds, chow chows, standard poodles, great danes,Italian greyhounds, and whippets.
What is it?
The disease may not appear until the dog is 4-18 months of age and may be delayed as long as 3-6 years. There is no noticed sex predilection. This condition is progressive with a gradual onset of dry, dull, and poor hair coat.
Several years after the onset of color dilution alopecia, hypotrichosis (abnormal hair patterns) begins and may progress until alopecia extends along the entire body sparing the head, tail, and limbs and any non-diluted coat areas. The skin in the affected area is usually scaly and follicular papules may develop and may progress to recurrent bacterial folliculitis. Abnormal clumps of melanin are often present in the epidermis, dermis, and epithelia of hair follicles. Aside from these coat and skin conditions, dogs with color dilution alopecia appear to be in good general health.
Genotypes and Phenotypes
- DD - unaffected
- Dd1 - also unaffected, but a carrier for the gene
- and d1d1 - affected by color dilution alopecia
As such, athe only way to have offspring which express color dilution alopecia is to breed two parents who are both affected by the disorder. If a dog with the genotype DD (unaffected) and a dog with the genotype Dd1, or two Dd1 dogs, were bred, the offspring would potentially be carriers of the genes that cause this disorder.
Not all dogs with the dilution genes develop alopecia or other coat abnormalities. There are multiple levels of abnormalities such as:
- abnormal keratinization
- abnormalities of pigment transfer
- defects in melanization
- abnormal storage of undegraded melanosomes
- defects of hair follicle function.
While no active measures are being taken to eradicate this genetic condition, the vital prognosis is good and it is recommended not to breed individuals with this condition in order to prevent transmission.
2. "Derm Digest Newsletter." Animal Dermatology Clinics. N.p., August 2010. Web. 28 Apr. 2016.
3. Kim, Jae-Hoon, Kyung-Il Kang, Hyun-Joo Sohn, Gye-Hyeong Woo, Young-Hwa Jean, and Eui-Kyung Hwang. "Color-dilution Alopecia in Dogs." Journal of Veterinary Science 6.3 (2005): 259-61. Web. 28 Apr. 2016.
4. Perego, Roberta, Daniela Proverbio, Paola Roccabianca, and Eva Spada. "Color Dilution Alopecia in a Blue Doberman Pinscher Crossbreed." The Canadian Veterinary Journal 50.5 (2009): 511-514. The Canadian Veterinary Journal. Canadian Veterinary Medical Association. Web. 28 Apr. 2016.
5. Phillip, U., H. Hamann, L. Mecklenburg, S. Nishino, E. Mignot, A. R. Gunzel-Apel, S. M. Schmutz, and T. Leeb. "Polymorphisms within the Canine MLPH Gene Are Associated with Dilute Coat Color in Dogs." BMC Genetics 6.34, 2005 Web. 28 Apr. 2016.
Kim, Jae-Hoon, Kyung-Il Kang, Hyun-Joo Sohn, Gye-Hyeong Woo, Young-Hwa Jean, and Eui-Kyung Hwang. "Color-dilution Alopecia in Dogs." Journal of Veterinary Science 6.3 (2005): 259-61. Web. 28 Apr. 2016.