The Antibiotics Resistance

E. coli Producing ESBL Versus non-ESBL


Worldwide data show that there is increasing resistance among urinary tract pathogens to conventional drugs. Escherichia coli is one of the most frequent causes of many common bacterial infections including urinary tract infection. E. coli isolates from the hospital infections were highly susceptible to many antimicrobial agents with the exception of those isolates producing extended-spectrum β-lactamases (ESBLs).


The aim of this study was to determinate the antibiotic resistance of Esherichia coli producing extended-spectrum β-lactamases isolated from hospitalized patients at Emergency Country Hospital Targu Mures, Romania, as well as comparing their resistance with those non-extended-spectrum β-lactamases.
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For this study, we enrolled 455 patients with symptomatic urinary tract infection and positive E. coli, including Esherichia coli producing extended-spectrum β-lactamases(n=99) and E. coli non-ESBL(n=356). During 2011 to 2015, E. coli from urine samples of patients attending urology department were collected from the Emergency County Hospital Targu Mures.


The resistance of E. coli producing extended-spectrum β-lactamases resistances has been studied for more antibiotics: Nalidixic acid(99,0%), Amikacin(2,4%), Ampicillin(96,6%), Ceftazidime(95,7%), Ciprofloxacin(98,7%), Cefepime(94,4%), Cefotaxime(98,2%), Cefuroxime(100%), Gentamicin(58,8%), Imipenem(1,1%), Meropenem(2%), Nitrofurantoin(9,4%), Norfloxacin(96%) and Levofloxacin(91,7%). In contrast, we study the antibiotic resistance for non-ESBL using Graph Pad Prism 6.0 and we obtained the following results: Nalidixic acid(49,7%, p<0,0001), Amikacin(4,1%, p=0,598), Ampicillin(66,2%, p<0,0001), Ceftazidime(4%, p<0,0001), Ciprofloxacin(38,4%, p<0,0001), Cefepime(3,8%, p<0,0001), Cefotaxime(4,3%, p<0,0001), Cefuroxime(5,8%, p<0,0001), Gentamicin(10%,p<0,0001), Imipenem(4,4%, p=0,215), Meropenem(13,3%, p=0,029), Nitrofurantoin(5,8%,p=0,081), Norfloxacin(40,1%,p<0,0001) and Levofloxacin(45,7%, p<0,0001).
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Because antibiotics resistance patterns are continually evolving, properly designed and conducted regional surveillance studies will continue to be essential to ensure the provision of safe and effective empiric therapy. It is quite alarming to note that almost all of the isolates included in this study were found resistant to four or more antibiotics. However , even if a specific antibiotic has a high sensitivity , however, it should not be given because while it would produce and endurance.


Jugariu Anamaria Romina