How HPV Causes Cancer
Michael LIppincott and Mitchell povich
What is HPV?
- Stands for Human papillomavirus
Is a group of 150 related viruses
Some types can lead to warts (papillomas)
Can lead to cancer (especially cervical)
40 types can infect the genital region of males and females
Transmitted through skin-to-skin contact
Most common STI
Genes that cause HPV
E1, E4, E6, and E7 are the most common HPV gene regions. Each gene has multiple different activation sites(areas to turn on/off genes).
How HPV Proteins Affect Host Cells
Expresses proteins E1, E2, E5, E6, and E7 early in the infection
- Proteins E7 and E6 hinder terminal differentiation which allows the host cell to continue to produce viruses.
- proteins--L1 and L2--and E4 are upregulated in HPV They promote viral production and exfoliate the cell
How does HPV Cause Cancer
Microbewiki. (2011, July 23). Human Papillomavirus and Cervical Cancer. Retrieved from https://microbewiki.kenyon.edu/index.php/Human_Papillomavirus_and_Cervical_Cancer
Medscape. (n.d.). Medscape Log In. Retrieved from http://www.medscape.com/viewarticle/732740_2
CDC. (2015, January 22). What is HPV? Retrieved from http://www.cdc.gov/hpv/whatishpv.html