ipratropium bromide

Atrovent HFA

Class:

anticholinergic



Short Acting Muscarinic Antagonist (SAMA)

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Uses:

Bronchodilator for the maintenance treatment of bronchospasms associated with COPD and not indicated for the initial treatment of acute episodes of bronchospasms where rescue therapy is required. Also available with albuterol.

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Routes/Dosage:

Available as:


Nebulization solution: 500mcg/unit dose t.i.d., q.i.d.

Atrovent HFA MDI: 2 puffs q.i.d.


ipratropium bromide and albuterol

Duoneb 3mls q.i.d.

Combivent, Respimat 2 puffs q.i.d.

Contraindications/precautions:

Contraindicated in patients with hypersensitivity to ipratropium or atropine.

Closely monitor patients with urinary retention and glaucoma.

FDA pregnancy Category B

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Minimal side effects but can include dry mouth, flushed skin, tachycardia, palpitations, and headache.

Drug interactions:

Concurrent use with other adgrenergic agents will have additive adgrenergic side effects.

MAOIs and TCA may lead to hypertensive crisis. Beta-blockers may decrease therapeutic effect.

Pharmacokinetics:

onset: within minutes

peak effect: 1-2 hours

duration: 4-8 hours

elimination: half life 2 hours

references:

Drug Guide for Nurses 11th edition

Integrated Cardiopulmonary Pharmacology 4th edition