BIO1025 Medical Topic Research Blog
Topic: Amyotrophic Lateral Sclerosis by Ali Groskreutz
Sources of Information
2. ProQuest Research Library http://search.proquest.com.ezproxy.unwsp.edu/pqrlhealth/docview/198983166/A20F6BFB89D144A4PQ/1?accountid=12915
3. Cochrane Database of Systematic Reviews 2 http://eds.b.ebscohost.com.ezproxy.unwsp.edu/ehost/detail/detail?sid=3eb23161-228d-4e1c-b753-43cd9290c53b%40sessionmgr102&vid=0&hid=126&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl&preview=false#AN=CD011742&db=chh
4. The ALS Association http://www.alsa.org
a- (P): lack of
my/o (R): muscle
-troph (S): nourishment
-ic (S): pertaining to
pertaining to lack of muscle nourishment; lack of nerve stimulation of the muscle may cause the wasting away of its tissue
scler (R): hardening
-osis (S): condition
abnormal hardening of body tissue
dys- (P): difficult
-phagia (S): to eat, to swallow
difficulty in swallowing
spastic (R): convulsive
-ity (S): condition
the condition of increased muscular tone causing stiff and awkward movements
sial/o (CF): salivary
-rrhea (S): flow, discharge
excessive flow of saliva
The initial involvement of anterior horn cells and corticomotor neurons and the location of the initial symptoms can distinguish ASL from similar diseases such as primary lateral sclerosis, primary muscular atrophy, and progressive bulbar palsy (Ng, 2015). ALS is recognizable by the appearance of communication deficits, weakness, decreased mobility, spasticity, dysphagia, pain and more symptoms varying in patients (Ng, 2015).
Normal Nerve Cell and Muscle vs. ALS Nerve Cell and Muscle
Motor Neurons Throughout the Body
More About ALS
Death of patients with ALS usually occurs two to four years after the disease has been diagnosed (Ng, 2015), and unfortunately, there is no cure. However, there are treatments and therapies that can slow the progression and lessen the symptoms of this fatal disease. For example, mechanical ventilation, used for those with significant respiratory muscles weakness, spasticity treatments such as stretching, and prescription and non-prescription medication, sialorrhea treatments such as suction and irradiating the salivary glands (Ng, 2015). Cell based therapies are also used and include the use of stem cells and replacement cells (Abdul Wahid, 2015).
Many epidemiologists have hypothesized of variety of causes of ALS, proposing the effects of heavy-metal toxins, and environmental and occupational exposures (Mitchell, 2007), although little is still known about the pathogenesis and overall epidemiology of ALS.
30,000 Americans are victims of ALS and over 5,600 are diagnoses every year (ALSA, 2015).
What is Motor Neuron Disease?
Motor Neurons Throughout the Body: http://stemsupplement.com/treatment-of-motor-neuron-disease-with-stem-cell-supplement/