Hemophilia A
By Leah Keogh
What is Hemophilia A?
Inheritance & Carriers
A woman would be a carrier if she were:
- The biological daughter of a man with hemophilia
- The biological mother of more than one son with hemophilia
- The biological mother of one son with hemophilia and has at least one other blood relative with hemophilia
A carrier test is a blood test that evaluate the X chromosome in the 23rd pair to find the mutation that causes hemophilia in that DNA, that could possibly run in the family. Carrier tests are not always 100% accurate, and sometimes won't give you the results you are looking for.
Chromosome 23
"F8 Gene." Genetics Home Reference. N.p., n.d. Web. 07 Dec. 2015.
Genetic Inheritance
"Hemophilia Genetics." Homecare for the Cure. N.p., n.d. Web. 04 Dec. 2015.
Hemophilia Patient
"Sadness & Happiness." : Egyptian Hemophilia Needs Your Attention. N.p., n.d. Web. 07 Dec. 2015.
How Hemophilia affects your health
Symptoms
Excessive bleeding from cuts or injuries
Many large or deep bruises
Unusual bleeding after vaccinations
Pain, swelling or tightness in joints
Nosebleeds without a known cause
Painful, excessive headache
Repeated vomiting
Extreme fatigue
Neck pain
Double vision
Complications
Joint Damage and deformation
Inhibitors-Antibodies against blood transfusion
Viral infection-from different blood
Excessive bleeding/blood loss
- Excessive Bruising
Treatment
Current Treament
Research Outlook
Researchers are looking for the possibility of treating the disorder with gene therapy.
Testing on a type of adult stem cell, so that they produce high levels of clotting factor VIII.
Researchers want to begin to engineer these mesenchymal stem cells.
Other facts about Hemophiliacs and their disorder
- Around 75% of Hemophiliacs globally do not receive treatment due to lack of resources
- Hemophilia occurs in about 2.2% of males
- Over time bleeds in joints can cause arthritis
- 1/3 of cases of Inherited Hemophilia A it appears with no previous history in the family of actually having the disorder.
- Around 17,000 people have Hemophilia in the U.S.
Websites to visit for more information
http://www.medicinenet.com/hemophilia/page5.htm
http://www.ncbi.nlm.nih.gov/pubmed/16276463
http://www.wakehealth.edu/Research/WFIRM/Projects/Researching-a-Treatment-for-Hemophilia.htm
http://ghr.nlm.nih.gov/condition/hemophilia
https://www.hemophilia.org/Bleeding-Disorders/Types-of-Bleeding-Disorders/Hemophilia-AWorks Cited
"Hemophilia." Symptoms. N.p., n.d. Web. 02 Dec. 2015.
"Complications of Having a Bleeding Disorder - Hemophilia Federation of America." Hemophilia Federation of America Complications of Having a Bleeding Disorder Comments. N.p., n.d. Web. 02 Dec. 2015.
"The Complications of Hemophilia." - Canadian Hemophilia Society. N.p., n.d. Web. 02 Dec. 2015.
"Result Filters." National Center for Biotechnology Information. U.S. National Library of Medicine, n.d. Web. 04 Dec. 2015.
"Hemophilia Symptoms, Causes, Treatment - What Are Treatments for Hemophilia? - MedicineNet." MedicineNet. N.p., n.d. Web. 04 Dec. 2015.
"Researching a Treatment for Hemophilia." - Wake Forest School of Medicine. N.p., n.d. Web. 07 Dec. 2015.