Huntington's Disease

By Anna Whitworth and Kaitlyn Gramata

The scientific name for Huntington's Disease

The scientific name for Huntington's Disease is Huntington's chorea

How can you get Huntington's Disease, how is it inherited?

Huntington's disease is caused by an inherited defect in a single gene. Huntington's disease is an autosomal dominant disorder, which means that a person needs only one copy of the defective gene to develop the disorder.

What chromosome is it that the Disorder is located?

The disorder is located in the 4th chromosome out of the 24. It comes when the chromosome is three times the size it is meant to be.

What are the symptoms of the disorder?

Cognitive: amnesia, delusion, lack of concentration, memory loss, mental confusion, slowness in activity and thought, or difficulty thinking and understanding

Muscular: abnormality walking, increased muscle activity, involuntary movements, problems with coordination, loss of muscle, or muscle spasms

Behavioral: compulsive behavior, fidgeting, irritability, or lack of restraint

Psychological: delirium, depression, hallucination, or paranoia

Mood: anxiety, apathy, or mood swings

Also common: tremor, weight loss, or impaired voice

What caused it? What gene or chromosome is affected by this disorder?

Huntington's disease is caused by mutations in a gene which produces a protein called Huntington. The role that this protein plays in normal brain function is not well understood.

Could this disorder have been prevented?

It is a genetically transmitted disease. You do not "catch" Huntington's Disease, nor is there a prevention of it. If a parent has Huntington's, there is a 50-50 chance that any child of that parent may develop it at some point. The website for the Huntington's Disease Society of America has some good information.

What population is affected? Can anyone be a candidate for the disorder?

Experts estimate that one in every 10,000 people 30,000 in the United States—have Huntington's disease. Juvenile Huntington's occurs in approximately 16 percent of all cases. Huntington's disease (HD) chromosomes with multi-allele markers revealed 26 different haplotypes, suggesting a variety of independent HD mutations. The most frequent haplotype, accounting for about one third of disease chromosomes, suggests that the disease gene is between D4S182 and D4S180. However, the paucity of an expected class of chromosomes that can be related to this major haplotype(a set of genetic determinants located on a single chromosome.) by assuming single crossovers may reflect the operation of other mechanisms in creating haplotype diversity.

Are there any treatments, medications, or therapies available to them?

No treatments can alter the course of Huntington's disease. But medications can lessen some symptoms of movement and psychiatric disorders. And multiple interventions can help a person adapt to changes in his/her abilities for a certain amount of time. Medication management is likely to evolve over the course of the disease, depending on the overall treatment goals. Also, drugs to treat some symptoms may result in side effects that worsen other symptoms. Therefore, the treatment goals and plan will be regularly reviewed and updated.

Medications/Treatments/Therapies

Tetrabenazine : Xenazine chorea.

Antipsychotic drugs : Haldo, chlorpromazine, and dystonia.

Other medications such as : amantadine, levetiracetam, and clonazepam.

SSRI antidepressants - such as fluoxetine, citalopram and paroxetine

Tricyclic antidepressants - such as amitriptyline

Other types of antidepressants - including mirtazapine, duloxetine and venlafaxine

Pedigree chart

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(K) Citations

"Bing." Huntington's Disease Chromosome. Web. 22 Mar. 2016.

"Bing." Huntington's Disease Human Pictures. Web. 22 Mar. 2016.

"Bing." Huntington's Disease Alleles. Web. 22 Mar. 2016.