By Micah Jacks
What is it?
A possibly congenital genetic disorder
- Inherited autosomal dominant pattern
- Most often, the affected person has a parent with it
- Only rare cases don't have a family history of it
- some cases of types II and IV: have an autosomal recessive inheritance
- Types II and IV: usually the parents of a person with W.S. with an autosomal recessive form both carry one copy of the altered gene, but no symptoms
- Partial albinism
- Extreme pale blue eyes or heterochromia
- Wide set nasal bridge and eyes
- Cleft lip (rare)
- White patch of hair above forehead (forelock)/ early graying of hair
Treatment is selected based on the symptoms (deafness, constipation).
- Affects 1 in 40,000 people
- 2% to 5% of cases with congenital hearing loss have W.S.
- Types I and II are common, III and IV are rare