Progeria

Biology Genetic Research Project

Why I Chose This Disease

I chose this disease because I believe its's an unique disease and believe children with this disease should be noticed for the pain and suffering they go through.

What is progeria? what are the symptoms?

Progeria is a rare disease that only occurs 1 in 4-8 milion newborns worldwide. This disease makes children age at a very young age. Progeria is mostly noticed by the features of the face and body structure. It causes children to go bald, have a small chin, swollen veins, narrow chest, age spots and absence of eye brows and eye lashes.

What Causes Progeria?

A mutation occurs in the gene called LMNA. This mutation produces the protein called progerin, this protein makes the nucleus unstable. It deforms the nucleus, and the instability of the nucleus makes premature aging occur and disease in progeria. Progeria is a "sporadic autosomal dominant" mutation. "Sporadic" means rare or irregular occurrence, "autosomal" is the chromosome it occurs in, and dominant is the type of gene it is, it over powers all recessive genes. since progeria is autosomal, male or female can inherit it.

diagnosis and treatment

They diagnosis progeria by genetically testing the LMNA mutations. If it comes out that you have progeria, sadly, there is no cure for progeria. Most patients go thorough physical therapy and take mild medications to help the symptoms or abnormal occurrences.

what i discovered

  • Progeria was first found in 1886 and started treatment and research in 1904.
  • Progeria don't effects the mind.
  • It can not be passed down by parents, its a mutation.
  • When you have progeria, you have a huge risk of getting heart disease.
  • Progeria isn't curable.
Progeria: A Growing Hope
Living With Rapid-Aging Disease Progeria
Introduction to Progeria Syndrome
Twins! Adalia and Natalia
Hutchinson-Gilford Progeria Syndrome (UNC-Charlotte)