Hope for Overeaters?
Emma Benney NTRN Health Care
In the article, Hope for Overeaters? Feeling Full May Have a Chemical ‘Switch,’ published on March 1, 2016 by Sara G. Miller; a new study conducted on mice may suggest that a chemical in the brain may initiate a feeling of fullness. This certain enzyme responds to the hormone leptin. This particular hormone is released by adipose tissue, which further binds to leptin receptors. Leptin indicates the feeling of fullness, and initiates signals throughout the body to let the body know when it has consumed enough food. However, people who gorge on food have high leptin levels and are therefore unable to recognize overeating as a result of desensitized receptors. In this recent study, an enzyme called HDAC5 was discovered to play a position leptin pathway. The mice that were unable to produce HDAC5 were resistant to leptin, causing them to gain weight. Counteracting this finding, mice that produced a surplus of this enzyme did not gain as much weight as anticipated while fed a high-fat diet. Being able to regain the sensitivity of leptin is important in terms of maintaining a healthy weight and overall health.