Neurological Disorder


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What is Alzheimer?

Alzheimer's disease; most common form of dementia is caused by brain cells deteriorating in the brain. Some of the long term effects are failing attention, memory loss, irritability and orientation

Who is likely to get Alzheimer?

Alzheimer's disease affects people of age 65+ although up to 5% of people with Alzheimer has had it at an early age; young onset, which appears around their 40's or 50's.
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How it works

During the clinical stage of Alzheimer’s disease toxic changes are taking place in the brain. Abnormal deposits of proteins form amyloid plaques and tau tangles throughout the brain, and neurons begin to work less efficiently. Over time, neurons lose their ability to function and communicate with each other. They eventually die out. The damage spreads to a nearby structure in the brain called the hippocampus, which is essential in forming memories. As more neurons die, affected brain regions begin to shrink. By the final stage of Alzheimer’s, damage is widespread, and brain tissue has shrunk significantly.

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Changes in tau protein lead to the disintegration of micro-tubules in brain cells.
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Two of the main features found in brains diseased with Alzheimer are neurotically tangles made up of a protein called tau, and senile plaques. The tau proteins that form the tangles previously held together a structure inside the neurons called a micro-tubule which is an important part of the neuron; it forms part of the cytoskelton which is what maintains a cell's shape, and micro-tubules plays a part in cell communication. Both tangles and plaques may be caused by other diseases, is being investigated as a possible cause or contributor in developing Alzheimer's.

Hereditary or ?

Although researcher have not found the cause of Alzheimer they do think it might me hereditary. Genetic research has reached evidence of a link between Alzheimer's disease and genes on four chromosomes, 1, 14, 19, and 21. The DNA of these families, researchers have found an abnormality in one gene on chromosome 21 that is common to a few of the families.
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Although there is no cure for Alzheimer's disease there are pills to delay or slow down the deterioration in one's body.