2004 Chemistry Nobel Price Winners
Irwin Rose, Avram Hershko, Aaron Ciechanover
-Graduate from Hadassah Medical School, doctorate in biochemistry from Technion- Israel Institute of Technology
-Working at Technion - Israel Institute of Technology
-Ciechanover was born in Haifa, British Protectorate of Palestine (Israel), a month before it became recognized by the United Nations as an independent country. His parents moved from Poland to the British territory in the mid-1920.
-Avram Hershko and Aaron Ciechanover worked in the lab with Irwin Rose at Fox Chase Cancer Center in Philadelphia.
-For many years they tried to reproduce protein without cells.
-After having no success without cells, the scientists tried to study how a cell can regulate the presence of a certain protein by making unwanted proteins with something called ubiquitin.
-Ubiquitin is a chemical compound forms very stable bonds with various proteins.
-Proteins are broken down in detail and when they are sent to be broken down they are labeled with ubiquitin.
-Cells label the proteins that need to be broken down with ubiquitin.
-They learned how a cell controls a number of important biochemical processes.
Why Does This Matter?
-Cervical cancer and cystic fibrosis are two examples of illness from the failure of cell degradation.
-Knowledge of ubiquitin labelled protein degradation allows scientists to make drugs against these diseases and many others.
-Mainly built on already known knowledge.
-In the future, this information will continue to help fight life threatening diseases such as cancer.